Description. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug. The strategies for interfering with the key events in the viral replicative cycle have the potential to target virtually all important human viral pathogens. This article focuses on approaches targeted at specific processes in viral infection, including virus adsorption, virus‐cell fusion, Cited by: Jan 01,  · Antiviral drug design could, in principle, be targeted at either viral proteins or cellular adkcap.org by:

Antiviral drug strategies adobe

Read "Antiviral Drug Strategies" by Raimund Mannhold available from Rakuten Kobo. Sign up today and get $5 off your first purchase. By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready Author: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers. Description. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Strategies of Antiviral Drugs: (ii) Many animal viruses enter the host cells by an endocytic pathway in which the virion — either with or without envelope — are endocytosed, and the un-coating and release of nucleic acid take place in the endocytic vesicle. A possible target site of an antiviral drug could be prevention of un-coating. The strategies for interfering with the key events in the viral replicative cycle have the potential to target virtually all important human viral pathogens. This article focuses on approaches targeted at specific processes in viral infection, including virus adsorption, virus‐cell fusion, Cited by: Antiviral drugs are believed to reduce disease severity and duration of a large Strategic National Stockpile (SNS) of antiviral drugs (18), and. Nat Rev Drug Discov. Jan;1(1) Strategies in the design of antiviral drugs. De Clercq E(1). Author information: (1)Rega Institute for Medical Research . Despite the considerable success achieved in immunization and antiviral drug development, many viruses lack effective treatment strategies. The primary. PDF Adobe pdf file icon Host-based antipoxvirus therapeutic strategies: turning the tables. Anthony S. Fauci Traditional antiviral drugs are generally directed against the proteins and functional pathways of the virus itself. Abstract. Antiviral drug resistance is a matter of great clinical importance that, historically, has been 'Error catastrophe and antiviral strategy'.

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Antiretrovirals and the HIV Pandemic, time: 5:51
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